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Ranolazine and St. John's wort

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Ranolazine is contraindicated in patients: … Taking inducers of CYP3A … CYP3A inducers (e.g., rifampin, phenobarbital, St. John's wort)”
Ranolazine extended-release, section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Ranolazine · St. John's wort

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.