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Safinamide and St. John's wort

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“XADAGO is contraindicated in patients with: … St John's wort”
Xadago (safinamide), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Safinamide · St. John's wort

Educational reference only. Not FDA-cleared. The Prescribing Information governs.