All pairs

Sodium oxybate and Zolpidem

Desk tier: Avoid together

Mechanism: GHB × CNS depressant (coma / apnea)

“Xyrem is contraindicated for use in: •combination with sedative hypnotics”
Xyrem (sodium oxybate), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Sodium oxybate · Zolpidem

Educational reference only. Not FDA-cleared. The Prescribing Information governs.