Ergotamine and Erythromycin

Desk tier: Avoid together

Mechanism: moderate CYP3A4 inhibition of clearance (↑ exposure)

“Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) … ergotamine use is contraindicated with these drugs”

Cafergot (ergotamine/caffeine), section CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Ergotamine · Erythromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.