Paxlovid (nirmatrelvir/ritonavir) and Lovastatin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A”

Paxlovid (nirmatrelvir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Paxlovid (nirmatrelvir/ritonavir) label, Contraindications

The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "HMG-CoA reductase inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.

Open source

PMID 9585793

1998 Clin Pharmacol Ther. Same map as simvastatin — and as red yeast rice / monacolin K.

Open source

Open this pair in the desk

All pairs for Paxlovid (nirmatrelvir/ritonavir) · Lovastatin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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