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Paxlovid (nirmatrelvir/ritonavir) and St. John's wort

Desk tier: Avoid together

Mechanism: labeled contraindication (labeled contraindication)

“PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers”
Paxlovid (nirmatrelvir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Paxlovid (nirmatrelvir/ritonavir) · St. John's wort

Educational reference only. Not FDA-cleared. The Prescribing Information governs.